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Nonalcoholic Fatty Liver Disease and the Gut Microbiome

By J. Boursier and A.M. Diehl


Recent progress has allowed a more comprehensive study of the gut microbiota. Gut microbiota helps in health maintenance and gut dysbiosis associates with chronic metabolic diseases. Modulation of short-chain fatty acids and choline bioavailability, lipoprotein lipase induction, alteration of bile acid profile, endogenous alcohol production, or liver inflammation secondary to endotoxemia result from gut dysbiosis. Modulation of the gut microbiota by pre/probiotics gives promising results in animal, but needs to be evaluated in human before use in clinical practice. Gut microbiota adds complexity to the pathophysiology of nonalcoholic fatty liver disease but represents an opportunity to discover new therapeutic targets

Topics: Animals, Carcinoma, Hepatocellular, Gastrointestinal Microbiome, Humans, Liver Cirrhosis, Liver neoplasms, Non-alcoholic Fatty Liver Disease, Severity of Illness Index
Publisher: 'Elsevier BV'
Year: 2016
DOI identifier: 10.1016/j.cld.2015.10.012
OAI identifier:
Provided by: Okina

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