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A long-term study of the interaction between iron and alcohol in an animal model of iron overload

By J. Olynyk, P. Hall, W. Reed, P. Williams, R. Kerr and M. Mackinnon

Abstract

Background/Aims: The hypothesis that chronic alcohol ingestion potentiates iron-associated liver injury was investigated in the ‘carbonyl iron-overload rat model’.\ud \ud Methods: Newborn male and female Wistar-Furth rats (seven per group) were used to investigate iron-alcohol interaction over a 26-week period. Groups 1 and 2 were iron loaded from birth, while the others received normal diet. At 10 weeks all rats commenced Lieber-DeCarli liquid diet; additional treatments were: group 1 6 g carbonyl iron/1000 ml diets plus alcohol; group 2 carbonyl iron in the liquid diet; group 3 alcohol in the liquid diet; group 4, the controls, received liquid diet only.\ud \ud Results: This study confirmed our previous observation that iron-loading from birth resulted in grade III–IV siderosis, in both male and female rats, and caused fibrosis associated with periportal macrophages. Alcohol-feeding, in addition to iron-feeding for 26 weeks significantly lowered the hepatic iron concentration in both male and female rats compared to those fed iron only (p<0.05). Alcohol feeding did increase hepatic fibrosis in the iron-loaded animals. However, serum alanine aminotransferase activity was significantly higher in the iron-alcohol group than in the other groups (p<0.05).\ud \ud Conclusions: Thus, contrary to expectation, chronic alcohol feeding failed to potentiate hepatic fibrosis in iron-overloaded rats, although there was rather more hepatocyte necrosis, and the serum alanine aminotransferase activity was significantly higher in the iron-alcohol group than in the other groups

Publisher: Elsevier
Year: 1995
OAI identifier: oai:researchrepository.murdoch.edu.au:19927
Provided by: Research Repository
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