De link tussen metabool syndroom en depressie.
Introduction: The metabolic syndrome (METS) affects a large part of society. Epidemiological research has found a connection between METS and depression. The most important biological systems that can play an important role in this connection are the HPA-axis and inflammation. Patients with METS, compared to patients without METS, appear to have moresymptoms that are also present in seasonal affective disorder (SAD), like increased appetite and weight gain. The goal of our research was to find if the prevalence of METS is higher in seasonal affective disorder. We also wanted to know if patients with METS show more seasonal affective symptoms compared to patients without METS. Material and method: The data from NESDA (The Netherlands Studie of Depression and Anxiety), the big cohort study with almost 3000 patients and controls, were used to research the relation between METS and SAD. We analysed the data from wave 2 and 3 of the cohortstudie. METS is defined according to the NCEP ATP III criteria and SAD has been determined using the seasonal pattern assessment questionnaire (SPAQ). With the pearson’s chi-squared tests we determined if the prevalence of METS or its components are higher in the patient group with SAD. We examined if patients with METS score higher on the SPAQ compared to the patient without METS by using linear regression. In the linear regression we corrected for covariabels. Results: We found no significantly higher prevalence of METS in the patient group with SAD (p=0,438) in the cross-sectional analysis of wave 2. However, the prevalence of METS components abdominal obesity (p=0,008), a low HDL cholesterol (p=0,010) and hypertension (p=0,001) were significantly higher in the SAD group compared to patients without SAD. We found a significantly higher prevalence of METS in the patient group with SAD (p=0,013) in the data from wave 3, obtained a year after the data of wave 2. The prevalence of abdominal obesity (p=0,000) and a low HDL cholesterol (p=0,048) were also significantly higher in this group. The results from the linear regression for both waves show significantly more seasonal affective symptoms for patients with METS (p=0,026 & p=0,050). Discussion: The results show a connection between METS and SAD. Based on pathological processes it appears that METS and SAD are most likely amplifying each other. New research has to determine the true character of this connection becausethis research is cross-sectional.