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Biosynthesis and processing of endogenous BDNF : CNS neurons store and secrete BDNF, not pro-BDNF

By T. Matsumoto, S. Rauskolb, M. Polack, J. Klose, R. Kolbeck, M. Korte and Y. -A. Barde

Abstract

Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input

Publisher: Nature America
Year: 2008
OAI identifier: oai:edoc.unibas.ch:3449
Provided by: edoc
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