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Heterogeneity of t(4;14) in multiple myeloma. Long-term follow-up of 100 cases treated with tandem transplantation in IFM99 trials.

By P. Moreau, M. Attal, F. Garban, C. Hulin, T. Facon, G. Marit, M. Michallet, C. Doyen, S. Leyvraz, M. Mohty, M. Wetterwald, C. Mathiot, D. Caillot, C. Berthou, L. Benboubker, L. Garderet, C. Chaleteix, C. Traullé, J.G. Fuzibet, J. Jaubert, T. Lamy, P. Casassus, M. Dib, B. Kolb, V. Dorvaux, B. Grosbois, I. Yakoub-Agha, J.L. Harousseau, H. Avet-Loiseau and and


One hundred de novo multiple myeloma patients with t(4;14) treated with double intensive therapy according to IFM99 protocols were retrospectively analyzed. The median overall survival (OS) and event-free survival (EFS) were 41.4 and 21 months, respectively, as compared to 65 and 37 for patients included in the IFM99 trials without t(4;14) (P<10(-7)). We identified a subgroup of patients presenting at diagnosis with both low beta(2)-microglobulin <4 mg/l and high hemoglobin (Hb) >/=10 g/l (46% of the cases) with a median OS of 54.6 months and a median EFS of 26 months, respectively, which benefits from high-dose therapy (HDT); conversely patients with one or both adverse prognostic factor (high beta(2)-microglobulin and/or low Hb) had a poor outcome. The achievement of either complete response or very good partial response after HDT was also a powerful independent prognostic factor for both OS and EFS

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 4; Cytarabine; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Genetic Heterogeneity; Hemoglobins; Humans; Male; Middle Aged; Multiple Myeloma; Multivariate Analysis; Prognosis; Retrospective Studies; Translocation, Genetic; Vincristine; beta 2-Microglobulin
Publisher: 'Springer Science and Business Media LLC'
Year: 2007
DOI identifier: 10.1038/sj.leu.2404832
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