Melan-A/MART-1-specific CD8 T cells: from thymus to tumor.
The self-antigen Melan-A/MART-1 is frequently involved in T-cell responses against malignant melanoma. The use of fluorescent tetramers incorporating the immunodominant Melan-A/MART-1 peptide has provided new insights into HLA-A2-restricted T-cell responses against this antigen in cancer patients and in healthy individuals. Direct evidence has been provided that a large Melan-A/MART-1-specific CD8 T-cell pool is generated during thymic selection. Although several other examples of naive self-peptide-specific T-cell repertoires are known, this is the only one directly accessible to analysis in healthy individual
Antigens, Neoplasm; Autoantigens/immunology; CD8-Positive T-Lymphocytes/immunology; Cancer Vaccines/immunology; Hematopoietic Stem Cells/immunology; Humans; MART-1 Antigen; Melanoma/immunology; Melanoma/prevention & control; Neoplasm Proteins/immunology; Thymus Gland/immunology
Publisher: 'Elsevier BV'
DOI identifier: 10.1016/S1471-4906(02)02244-5
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