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The regulation of differentiation in mesenchymal stem cells

By Andrea Augello and Cosimo De Bari


Peer reviewedPublisher PD

Topics: animals, cell differentiation, cells, cultured, chondrogenesis, gene expression regulation, developmental, humans, mesenchymal stem cells, mice, osteogenesis, signal transduction, transcription factors, transforming growth factor beta, Wnt proteins, QH426 Genetics, QH426
Year: 2010
DOI identifier: 10.1089/hum.2010.173
OAI identifier:

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  3. (2002). A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. doi
  4. (1998). A nude mouse model for human bone formation in unloaded conditions. doi
  5. (2001). Adult rat and human bone marrow stromal stem cells differentiate into neurons. Blood Cells Mol. doi
  6. (2004). Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. doi
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  10. (2001). BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. doi
  11. (2002). Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. doi
  12. (2010). Bone morphogenetic protein receptors and signal transduction. doi
  13. (2007). Bone morphogenetic protein. doi
  14. (1996). Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. doi
  15. (2005). Canonical Wnt/b-catenin signaling prevents osteoblasts from differentiating into chondrocytes. doi
  16. (2009). Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. doi
  17. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. doi
  18. (1992). Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. doi
  19. (2008). Cell therapy: A challenge in modern medicine.
  20. (2003). Cellular signaling in developmental chondrogenesis: N-cadherin, Wnts, and BMP-2.
  21. (1985). Characterization of cells with high alkaline phosphatase activity derived from human bone and marrow: Preliminary assessment of their osteogenicity. doi
  22. (1980). Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny.
  23. (1998). Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. doi
  24. (2001). Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components. doi
  25. (1999). Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells. I. Stimulation by bone morphogenetic protein-2 in high-density micromass cultures. doi
  26. (1999). Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells. II. Stimulation by bone morphogenetic protein-2 requires modulation of N-cadherin expression and function. doi
  27. (2000). Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model.
  28. (2008). Collagen 11a1 is indirectly activated by lymphocyte enhancerbinding factor 1 (Lef1) and negatively regulates osteoblast maturation. doi
  29. (2005). Comparison of effect of BMP-2, 4, and 6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res. doi
  30. (2005). Comparison of effect of BMP-2, 4, and 6o n in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res. doi
  31. (2009). Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. doi
  32. (2007). Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. doi
  33. (2007). Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair—current views. doi
  34. (2004). Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: Validation of an in vitro model for human bone marrow-derived primary osteoblasts. doi
  35. (2008). Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. doi
  36. (2009). Distinct mesenchymal progenitor cell subsets in the adult human synovium. Rheumatology (Oxford) doi
  37. (2006). Endogenous Wnt signaling promotes proliferation and suppresses osteogenic differentiation in human adipose derived stromal cells. doi
  38. (2006). Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. doi
  39. (1998). Expression and distribution of transforming growth factor-b isoforms and their signaling receptors in growing human bone. doi
  40. (2004). Expression profiling and functional analysis of Wnt signaling mechanisms in mesenchymal stem cells. doi
  41. (2004). Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo. doi
  42. (1997). Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. doi
  43. (1976). Fibroblast precursors in normal and irradiated mouse hematopoietic organs.
  44. (1980). Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. doi
  45. (2005). HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: Inducing cell expansion and reversibly preventing multilineage differentiation. doi
  46. (2002). High bone density due to a mutation in LDL-receptor-related protein 5. doi
  47. (2002). Human adipose tissue is a source of multipotent stem cells. doi
  48. (2007). Human and rodent bone marrow mesenchymal stem cells that express primitive stem cell markers can be directly enriched by using the CD49a molecule. Cell Tissue Res. doi
  49. (2001). Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age. doi
  50. (2006). Identifi-cation and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency. doi
  51. (2006). Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency. doi
  52. (2008). Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. doi
  53. (2009). Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes. doi
  54. (2002). In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. doi
  55. (1998). In vitro chondrogenesis of bone marrowderived mesenchymal progenitor cells.
  56. (1991). In vitro differentiation of bone and hypertrophic cartilage from periosteal-derived cells. doi
  57. (1994). Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. doi
  58. (2002). Integration of the TGF-b pathway into the cellular signalling network. doi
  59. Interactions between Sox9 and b-catenin control chondrocyte differentiation. doi
  60. (2002). Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. doi
  61. (2008). Isolation and characterization of mouse mesenchymal stem cells. doi
  62. (2009). Isolation and characterization of resident mesenchymal stem cells in human glomeruli. doi
  63. (2005). Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway. doi
  64. (2001). LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
  65. (2008). Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. doi
  66. (2006). Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts. doi
  67. (2003). Lymphoid enhancer factor-1 and b-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. doi
  68. (2001). M u k h a c h e v ,V . ,L a v r o u k o v ,A . ,K o n ,E . ,a n dM a r c a c c i ,M . doi
  69. (1997). Marrow stromal cells as stem cells for nonhematopoietic tissues. doi
  70. (2002). Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. doi
  71. (2006). Matrix elasticity directs stem cell lineage specification. doi
  72. (2005). Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. doi
  73. (2008). Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. doi
  74. (2006). Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis. doi
  75. (2006). Mesenchymal stem cells reside in virtually all post-natal organs and tissues. doi
  76. (2001). Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century. doi
  77. (2003). Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. doi
  78. (2009). MicroRNA transcriptome profiles during swine skeletal muscle development. doi
  79. (2009). MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1. doi
  80. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells: The International Society for Cellular Therapy position statement. doi
  81. (2008). miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation. doi
  82. (2010). miR-27 promotes osteoblast differentiation by modulating Wnt signaling. doi
  83. (2010). miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. doi
  84. (2001). Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo. doi
  85. (2009). Morphogenetic and regulatory mechanisms during developmental chondrogenesis: New paradigms for cartilage tissue engineering. doi
  86. (2002). Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. doi
  87. (1999). Multilineage potential of adult human mesenchymal stem cells. doi
  88. (2001). Multipotent mesenchymal stem cells from adult human synovial membrane. doi
  89. (1995). Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. doi
  90. (2005). N-cadherin mediated distribution of b-catenin alters MAP kinase and BMP-2 signaling on chondrogenesis-related gene expression. doi
  91. (2006). Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells.
  92. (2003). Observations of subchondral plate advancement during osteochondral repair: A histomorphometric and mechanical study in the rabbit femoral condyle. doi
  93. (2010). Opposite spectrum of activity of canonical Wnt signaling in the osteogenic context of undifferentiated and differentiated mesenchymal cells: Implications for tissue engineering. Tissue Eng. doi
  94. (1990). Osteogenic capacity of rat and human marrow cells in porous ceramics: Experiments in athymic (nude) mice. doi
  95. (2010). Osteogenic differentiation of mouse mesenchymal progenitor cell, Kusa-A1 is promoted by mammalian transcriptional repressor Rbpj. doi
  96. (1997). Osteogenic differentiation of purified, cultureexpanded human mesenchymal stem cells in vitro. doi
  97. (2008). PDGF receptor b is a potent regulator of mesenchymal stromal cell function. doi
  98. (2004). Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions. doi
  99. (2006). Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. doi
  100. (2010). Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering. doi
  101. (1998). Receptor tyrosine kinase expression in human bone marrow stromal cells. doi
  102. (2010). Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell Tissue Res. doi
  103. (1997). Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. doi
  104. (2001). Repair of large bone defects with the use of autologous bone marrow stromal cells. doi
  105. (2009). Role of membrane potential in the regulation of cell proliferation and differentiation. doi
  106. (2005). Runx2: A master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res. doi
  107. (2003). Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane. doi
  108. (2010). SOX9 determines RUNX2 transactivity by directing intracellular doi
  109. (1999). Specificity, diversity, and regulation in TGF-b superfamily signaling.
  110. (2008). Stem cells for tooth engineering.
  111. (1997). Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. doi
  112. (2009). Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. doi
  113. (2008). TGF-b and the TGF-b family. doi
  114. (2007). TGFb-SMAD signal transduction: Molecular specificity and functional flexibility. doi
  115. (2010). The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development. doi
  116. (2008). The bone morphogenetic proteins. doi
  117. (1970). The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. doi
  118. (2010). The effects of Wnt inhibitors on the chondrogenesis of human mesenchymal stem cells. doi
  119. (2008). Transcriptional control of skeletogenesis. doi
  120. (2003). Transforming growth factor-b-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. doi
  121. (2004). Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. doi
  122. (2009). Wnt and PPARg signaling in osteoblastogenesis and adipogenesis. doi
  123. (2006). Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. doi
  124. (2008). Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner. doi
  125. (2009). Wnt signaling as a therapeutic target for bone diseases. doi
  126. (2002). Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis. doi
  127. (2004). Wnt signaling in osteoblasts and bone diseases. doi
  128. (2006). Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors. doi
  129. (2005). Wnt/ b-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. doi

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