Skip to main content
Article thumbnail
Location of Repository

A randomised controlled trial evaluating the use of polyglactin mesh, polydioxanone and polyglactin sutures for pelvic organ prolapse surgery

By S Alladin, Cathryn Margaret Anne Glazener and Christine Bain


To compare the effectiveness of polyglactin mesh, and polydioxanone or polyglactin sutures in women having pelvic organ prolapse surgery. Randomised controlled trial with a factorial 2(2 design of polyglactin mesh or not, and polydioxanone or polyglactin suture. Outcomes were assessed using questionnaires at baseline and on the third day and at 6 months after surgery. Women were also examined clinically 3 months after surgery. The primary outcome was the subjective improvement in prolapse symptoms and quality of life scores from baseline to 6 months. There was a subjective improvement in the prolapse symptom score from baseline to 6 months after surgery (mean difference of 9.2 (95% CI for difference 7.2-11.2, p < 0.001) and an improvement in the mean quality of life score over the same period with a reduction of 3.4 (95% CI for difference 2.4-4.3, p < 0.001). However, there were no significant differences in the mean difference in prolapse symptoms and quality of life (QoL) scores according to the randomised groups. The majority (86%) of women were satisfied with their surgery. Our study demonstrated that at short-term follow-up, there was no significant difference in the mean differences in prolapse symptoms and QoL scores after surgery using polyglactin mesh or not, polyglactin or polyglactin sutures, but the numbers were too small for a definitive conclusion. Longer-term follow-up and/or a larger trial are required

Topics: pelvic organ prolapse, randomised control trial surgical mesh, polydioxanone, polyglactin
Publisher: Taylor & Francis
Year: 2008
OAI identifier:

Suggested articles


  1. (2001). al: Prospective randomized trial of polyglactin 910 mesh to prevent recurrences of cystoceles and rectoceles. doi
  2. (2001). Anterior colporrhaphy: A randomized trial of three surgical techniques. doi
  3. (1988). Biomaterials in hernia surgery. In: Inguinal hernia: advances or controversies? Arregui ME, Nagan RF.
  4. (1974). Experience with Mersilene mesh in abdominal wall repair. Proc R Soc Med
  5. (1997). Incidence and clinical characteristics of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol doi
  6. (1978). Plastic mesh repair of incisional hernias. doi
  7. (2007). Surgical management of pelvic organ prolapse in women (Cochrane Review). In: The Cochrane Database of Systematic Reviews, doi
  8. (2005). Synthetic biomaterials for pelvic floor reconstruction. Curr Urol Rep doi
  9. The role of synthetic and biological prostheses in reconstructive pelvic floor surgery. doi
  10. (2001). The use of synthetics in the treatment of pelvic organ prolapse. doi
  11. (2001). Validation of a new questionnaire for incontinence: doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.