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Survival from Uveal Melanoma in England and Wales 1986 to 2001

By Jennifer Margaret Burr, E. Mitry, B. Rachet and M.P. Coleman

Abstract

Purpose. To analyse survival from uveal melanoma diagnosed in England and Wales during 1986-1999 and followed up to 2001. Methods. Data from the National Cancer Registry at the Office for National Statistics were analysed. The data were compiled from population-based cancer registries covering all of England and Wales for all adults (aged 15-99) diagnosed with primary ocular malignancy, excluding eyelid tumours. Level of poverty was based on the national classification of area of residence at time of diagnosis. Regression models explored the influence of sex, age and level of poverty on relative survival for patients diagnosed with uveal melanoma during successive calendar periods. Results. Of 5,519 adults identified with primary ocular malignancy, 4,717 had melanoma, of which 4,308 (91%) were eligible for analysis. Two-thirds (67%) of the ocular melanomas were uveal, 5% conjunctival and 2% orbital; the sub-site was unspecified in 26%. Relative survival from uveal melanoma was 95% at one year and 72% at five years. There was no statistically significant variation in one-year or five-year survival by sex or poverty level, and no significant trend over time. Older patients had significantly worse survival (P<0.001). Conclusions. This study provides national population-based survival estimates for England and Wales for uveal melanoma, the most common primary intraocular malignancy in adults. Five-year relative survival, an important indicator of the quality of cancer care, has not improved since the 1980s. Greater age, but not gender or level of poverty, is associated with a poorer prognosis. A standardised classification of uveal melanoma is required to improve reporting to cancer registries. Further research is required to explore reasons for lower relative survival in older persons.The Health Services Research Unit at the University of Aberdeen is supported by a core grant from the Chief Scientist Office of the Scottish Executive Health Department

Topics: Melanoma, Survival Rate, Uveal Neoplasms
Publisher: Informa
Year: 2007
OAI identifier: oai:aura.abdn.ac.uk:2164/186
Journal:

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Citations

  1. (1998). A comparison of cause-specific melanoma mortality and all-cause mortality in survival analyses after radiation treatment for uveal melanoma. doi
  2. (1966). A review of mortality from choroidal melanoma. II. A meta-analysis of 5-year mortality rates following enucleation, doi
  3. An evaluation of enucleation in the management of uveal melanomas. doi
  4. Breast carcinoma survival in Europe and the USA: a population-based study. doi
  5. Calculation of survival rates for cancer.
  6. (1999). Cancer survival in Britain is poorer than that of her comparable European neighbours. BMJ
  7. Cancer survival trends in England and Wales, 1971-1995: deprivation and NHS Region, London: The Stationary Office; 1999: 449-56. 31 Finger PT. Do you speak ocular tumor?
  8. Childhood cancer survival in Europe and the United States. doi
  9. Choice of geographic unit influences socioeconomic inequalities in breast cancer survival.
  10. Completeness of cancer registration: a new method for routine use.
  11. (2004). Conservation of eyes with choroidal melanoma by a multimodality approach to treatment: an audit of 1632 patients. Ophthalmology doi
  12. Current trends in the treatment of ocular melanoma by radiotherapy. doi
  13. (1998). Delays in the diagnosis of uveal melanoma and effect on treatment. Eye doi
  14. (1998). Deprivation and late presentation of glaucoma: case-control study. doi
  15. (1995). Deprivation indices: their interpretation and use in relation to health. doi
  16. Detection of uveal melanoma by optometrists in the United Kingdom. doi
  17. (2003). Differences in colorectal cancer survival between European and US populations: the importance of sub-site and morphology. Eur.J.Cancer doi
  18. (2000). Environment Transport and the Regions. Measuring multiple deprivation at the small area level: the indices of deprivation. doi
  19. Geographical variation in life expectancy at birth in England and Wales is largely explained by deprivation. doi
  20. International uveal melanoma incidence trends in view of a decreasing proportion of morphological verification. doi
  21. (1999). Long-term survival after ruthenium plaque radiotherapy for uveal melanoma. A meta-analysis of studies including 1,066 patients. doi
  22. Micheli A et al. Toward a comparison of survival in American and European cancer patients. doi
  23. National Assembly for Wales. Welsh Index of Multiple Deprivation. National Assembly for
  24. (1991). Office for National Statistics. doi
  25. (2001). Office for National Statistics. Census
  26. (1975). Organisation. International Classification of Diseases, doi
  27. (1989). Organisation. International Statistical Classification of Diseases and Related Health Problems, doi
  28. (2001). Prognostic factors in uveal melanoma. doi
  29. Prognostic parameters in uveal melanoma: doi
  30. (2000). Psychological reactions and quality of life in patients with posterior uveal melanoma treated with ruthenium plaque therapy or enucleation: a one year follow-up study. Eye doi
  31. (2004). Recent increase in cancer survival according to age: higher survival in all age groups, but widening age gradient. Cancer Causes & Control doi
  32. Regression models for relative survival. doi
  33. (1990). Relative survival and the estimation of net survival: elements for further discussion. doi
  34. Ruthenium brachytherapy for uveal melanoma, 1979-2003: Survival and functional outcomes in the Swedish population. doi
  35. (1973). Survival rates with uveal melanoma in the United States: doi
  36. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings. doi
  37. (2004). The Zimmerman-McLean-Foster hypothesis: 25 years later. doi
  38. (2000). Tumor doubling times in metastatic malignant melanoma of the uvea: Tumor progression before and after treatment. Ophthalmology doi
  39. (1960). Uveal melanoma survival in Sweden from
  40. (2005). Uveal melanoma: Genetic aspects. Ophthalmol Clin North Am doi
  41. (2000). Ward level population estimates mid-1998. Social Disadvantage Research Group,

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