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Utility of B-type natriuretic peptide in predicting medium-term mortality in patients undergoing major non-cardiac surgery

By Brian Cuthbertson, Amir R. Amiri, Bernard L. Croal, Sriram Rajagopalan, Julie Brittenden and Graham S. Hillis


We assessed the ability of pre-operative B-type natriuretic peptide (BNP) levels to predict medium-term mortality in patients undergoing major noncardiac surgery. During a median 654 days follow-up 33 patients from a total cohort of 204 patients (16%) died. The optimal cut-off in this cohort, determined using a receiver operating characteristic curve, was >35pg.mL-1. This was associated with a 3.47-fold increase in the hazard of death (p=0.001) and had a sensitivity of 70% and a specificity of 68% for this outcome. These findings extend recent work demonstrating that BNP levels obtained before major noncardiac surgery can be used to predict peri-operative morbidity, and indicate that they also forecast medium-term mortality.This work was supported by a grant from TENOVUS Scotland. The Health Services Research Unit is core-funded by the Chief Scientists Office of the Scottish Executive Health Department.Peer reviewedAuthor versio

Topics: Biological Markers, Mortality, Postoperative Complications, Surgery, RD Surgery
Publisher: Elsevier
Year: 2007
DOI identifier: 10.1016/j.amjcard.2007.05.058
OAI identifier:

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