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A facile, catalytic, and environmentally benign method for selective deprotection oftert-butyldimethylsilyl ether mediated by phosphomolybdic acid supported on silica gel

By G.D.K. Kumar and S. Baskaran


An environmentally benign PMA supported on SiO2 is found to be an efficient catalyst for the chemoselective deprotection of TBDMS ethers under very mild conditions. Various labile functional groups such as isopropylidene acetal, OTBDPS, OTHP, Oallyl, OBn, alkene, alkyne, OAc, OBz, N-Boc, N-Cbz, N-Fmoc, mesylate, and azide are found to be stable under the reaction conditions. This “truly catalytic” heterogeneous reaction does not require aqueous workup, and the supported catalyst and the solvent can be readily recovered and recycled

Publisher: 'American Chemical Society (ACS)'
Year: 2005
DOI identifier: 10.1021/jo0502697
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Provided by: Enlighten
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