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Evaluation of a nanoemulsion-based formulation for respiratory delivery of budesonide by nebulizers

By Amir Amani, Peter York, Henry Chrystyn and Brian J. Clark

Abstract

The aim of this work was to evaluate the in vitro performance of a nebulized nanoemulsion formulation which had been optimised previously. To do so, a transparent nanoemulsion preparation containing 1.5 mg/ml of budesonide was prepared and diluted to achieve concentrations of 250 and 500 μg/ml budesonide. The in vitro characteristics of the diluted nanoemulsions were then compared with the commercially available suspension of budesonide (Pulmicort Respules®) when nebulized using a jet and a vibrating mesh nebulizer. A smaller MMAD with improved aerosol output was observed in the nanoemulsion preparations compared with the corresponding suspension formulations indicating an improved in vitro performance for the nanoemulsion-based preparation

Topics: Q1, R1
Publisher: Springer New York
Year: 2010
DOI identifier: 10.1208/s12249-010-9486-9
OAI identifier: oai:eprints.hud.ac.uk:8612
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