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A tetrahedral intermediate in the aminolysis of benzylpenicillin

By Nigel P. Gensmantel and Michael I. Page


There is a non-linear dependent of the rate of aminolysis of benzylpenicillin upon hydroxide ion concentration which is interpreted in terms of formation of a tetrahedral intermediate; the rate of breakdown of the intermediate into reactants is ca. 109 s–

Topics: Q1, QD
Publisher: Royal Society of Chemistry
Year: 1978
DOI identifier: 10.1039/c39780000374
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