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A reversible inhibitor of ?-lactamase I from Bacillus cereus

By Mark Jones, Stephen C. Buckwell, Michael I. Page and Roger Wrigglesworth

Abstract

a-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of -lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10–4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzym

Topics: Q1, QD
Publisher: Royal Society of Chemistry
Year: 1989
OAI identifier: oai:eprints.hud.ac.uk:6122
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