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HSV-1 not only in human vestibular ganglia but also in the vestibular labyrinth

By Viktor Arbusow, Diethilde Theil, Michael Strupp, Andrea Mascolo and Thomas Brandt

Abstract

Reactivation of herpes simplex virus type 1 (HSV-1) in the vestibular ganglion (VG) is the suspected cause of vestibular neuritis (VN). Recent studies reported the presence of HSV-1 DNA not only in human VGs but also in vestibular nuclei, a finding that indicates the possibility of viral migration to the human vestibular labyrinth. Distribution of HSV-1 DNA was determined in geniculate ganglia, VGs, semicircular canals, and macula organs of 21 randomly obtained human temporal bones by nested PCR. Viral DNA was detected in 48% of the labyrinths, 62% of the VGs, and 57% of the geniculate ganglia. The potential significance of this finding is twofold: (1) Inflammation in VN could also involve the labyrinth and thereby cause acute unilateral vestibular deafferentation. (2) As benign paroxysmal positional vertigo often occurs in patients who have had VN, it could also be a sequel of viral labyrinthitis. Copyright (C) 2001 S. Karger AG, Basel.

Topics: Medizin, ddc:610
Publisher: Ludwig-Maximilians-Universität München
Year: 2001
DOI identifier: 10.1159/000046131
OAI identifier: oai:epub.ub.uni-muenchen.de:17022
Provided by: Open Access LMU

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Citations

  1. Arbusow V: Acute vestibulopathy.
  2. Bell palsy and herpes simplex virus: Identification of viral DNA in endoneurial fluid and muscle. Ann Intern Med 1996;124:27–30. Schuknecht
  3. Herpes simplex virus infections of the central nervous system: A review.
  4. (1993). Inokuma T: Vestibular neuronitis: Epidemiological survey by questionnaire in Japan. Acta Otolaryngol (Stockh) Suppl
  5. Morphology of the vestibular nerve. I. Anatomical studies of the vestibular nerve in man.
  6. (1993). Nagashima K: Latent herpes simplex virus type 1 in human vestibular ganglia. Acta Otolaryngol (Stockh) Suppl
  7. (1991). Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid. Lancet
  8. T: Detection of herpes simplex virus type 1 in human vestibular nuclei.
  9. (1999). T: Distribution of herpes simplex virus type 1 in human geniculate and vestibular ganglia: Implications for vestibular neuritis. Ann Neurol
  10. (1998). T: Highly variable distribution of HSV-1-specific DNA in human geniculate, vestibular and spiral ganglia.
  11. (1988). Vestibular neuritis: A horizontal semicircular canal paresis? Adv Otorhinolaryngol
  12. (1981). Vestibular neuritis. Ann Otol Rhinol Laryngol Suppl
  13. Vestibular neuronitis: An otoneurological evaluation. Acta Otolaryngol (Stockh) Suppl 1988;453:1–72.

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