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Antipsychotic Response in the First Week Predicts Later Efficacy

By Ina Giegling, Stefano Porcelli, Beatrice Balzarro, Costanza Andrisano, Martin Schäfer, Hans-Jürgen Möller, Dan Rujescu and Alessandro Serretti


Background and Aims: Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. Methods: 86 acutely psychotic patients treated with haloperidol were studied. Results: A PANSS reduction <= 16% at 1 week predicts non-response at 3 weeks of treatment (specificity 92%, sensitivity 82%). Conversely, a PANSS reduction >= 23% at 1 week of treatment predicts response at 3 weeks, with a specificity of 84% and a sensitivity of 86%. Conclusion: Our results confirm that an early response to antipsychotic treatment accurately predicts the treatment effectiveness and extends it to a prediction performed as early as 1 week. Copyright (c) 2012 S. Karger AG, Basel

Topics: Medizin, ddc:610
Publisher: Ludwig-Maximilians-Universität München
Year: 2012
DOI identifier: 10.1159/000337739
OAI identifier:
Provided by: Open Access LMU

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