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Copper-catalysed multicomponent click synthesis of 5-alkynyl 1,2,3-triazoles under ambient conditions

By Francisco Alonso Valdés, Yanina Moglie, Gabriel Radivoy and Miguel Yus Astiz


Copper(I) oxide has been found to effectively catalyse the multicomponent click synthesis of fully substituted 5-alkynyl 1,2,3-triazoles from organic halides, sodium azide, and terminal ­alkynes in methanol under ambient conditions.This work was generously supported by the Spanish Ministerio de Ciencia e Innovación (MICINN; CTQ2007-65218 and Consolider Ingenio 2010-CSD2007-00006), the Generalitat Valenciana (GV; PROMETEO/2009/039), and Fondo Europeo de Desarrollo Regional (FEDER). Y. M. acknowledges the Instituto de Síntesis Orgánica (ISO) of the Universidad de Alicante for a grant

Topics: Alkynes, Alkyl halides, Azides, Cycloaddition, Copper, Cross-coupling, Heterocycles, Multicomponent reaction, Química Orgánica
Publisher: Georg Thieme Verlag
Year: 2012
DOI identifier: 10.1055/s-0031-1290445
OAI identifier:

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