Skip to main content
Article thumbnail
Location of Repository

Consequences of subacute intratracheal exposure of rats to cadmium oxide nanoparticles: Electrophysiological and toxicological effects

By András Papp, Gábor Oszlánczi, Edina Horváth, Edit Paulik, Gábor Kozma, András Sápi, Zoltán Kónya and Andrea Szabó


Cadmium is a metal used in various industrial applications, whereby exposure to Cd-containing fumes is likely. The submicron sized particles in the fumes represent an extra risk due to their high mobility within the organism and high surface area. Toxicity of Cd on the liver, kidney and bones is well known, but there are less data on its neurotoxicity. Here, male Wistar rats were treated for 3 and 6 weeks by intratracheal instillation of CdO2 nanosuspension. The treated rats’ body weight gain was significantly decreased, and in the high dose rats (0.4 mg/kg Cd daily) the weight of lungs and thymus was significantly increased. In this group, the spectrum of spontaneous cortical electrical activity was shifted to higher frequencies, the latency of sensory evoked potentials was lengthened, and the frequency following ability of the somatosensory evoked potential was impaired – even without detectable Cd deposition in the brain. The data support the role of the nano-sized Cd in the causation of nervous system damage and show the possibility of modeling human neurotoxic damage in rats

Topics: R1 Medicine (General) / orvostudomány általában
Publisher: SAGE Publications
Year: 2012
DOI identifier: 10.1177/0748233711430973
OAI identifier:

Suggested articles


  1. (1982). A comparative study of superoxide dismutase, catalase and lipid peroxidation in red blood cells from muscular dystrophy patients and normal controls. doi
  2. (1972). A role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.
  3. (2003). A study on electrophysiological effects of subchronic cadmium treatment in rats. doi
  4. (2002). Air pollution and brain damage. doi
  5. (2001). Amyotrophic lateral sclerosis in a batteryfactory worker exposed to cadmium. doi
  6. (2004). An improved understanding of soil Cd risk to humans and low cost methods to phytoextract Cd from contaminated soils to prevent soil Cd risks. doi
  7. (2009). Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots. doi
  8. (1999). Cadmium. A possible etiological factor in peripheral polyneuropathy.
  9. (1999). Changes in EEG spectral power in the prefrontal cortex of conscious rats elicited by drugs interacting with dopaminergic and noradrenergic transmission. doi
  10. (1986). Diethyldithiocarbamate increases distribution of cadmium to brain but prevents cadmium-induced neurotoxicity. doi
  11. (1994). disposition of inhaled cadmium oxide aerosol in the rat. doi
  12. (1985). Dissolution of metals by human and rabbit alveolar macrophages. doi
  13. (1968). Estimation of total protein-bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. doi
  14. (1984). Evoked potentials related to hair cadmium and lead in children. doi
  15. (2005). Exposure to lead, cadmium and chromium among spray painters in automobile body repair shops. doi
  16. (2004). Fate and toxic effects of inhaled ultrafine cadmium oxide particles in the rat lung. doi
  17. (1994). Human respiratory tract model for radiological protection. A report of a task group of the doi
  18. (2002). Immuno- and neurotoxicological investigation of combined subacute exposure with the carbamate pesticide propoxur and cadmium in rats. doi
  19. (1990). Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thio-acetamide-induced acute liver failure. doi
  20. (1995). Lead, chromium and cadmium emission factors during abrasive blasting operations by bridge painters. doi
  21. (2007). Lukács A and Szab A
  22. (1985). Main and interaction effects of metallic toxins on classroom behavior. doi
  23. (2005). Metals, toxicity and oxidative stress doi
  24. (2005). Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. doi
  25. (2000). Neurobehavioural effects of occupational exposure to cadmium: a cross sectional epidemiological study.
  26. (1991). Possible role of Ca2+ in the heavy metal cytotoxicity. doi
  27. (1951). Protein measurement with Folin phenol reagent. doi
  28. (2003). Pulmonary effects of welding fumes: review of worker and experimental animal studies. doi
  29. (1979). The clearance of cadmium aerosols after inhalation exposure. doi
  30. (1999). The effect of cadmium on somatosensory evoked potentials (SEP) and conduction velocity in alloxane-induced diabetic rats: relation to lipid peroxidation. doi
  31. (2008). Toxicological profile for cadmium, draft for public comment (update).
  32. (2003). Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environmental Health Perspectives 4: 455-460. 12 Lpez E, Arce C, Oset-Gasque MJ, doi
  33. (1996). Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. doi
  34. (1997). Ventilation and metabolism among rat strains

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.