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Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems

By Noraini Ahmad, Roland Ramsch, Meritxell Llinas, Conxita Solans, Rauzah Hashim and Hairul Anuar Tajuddin

Abstract

The effect of incorporating new nonionic glyco lipid surfactants on the properties of a model water/nonionic surfactant/oil nano-emulsion system was investigated using branched-chain alkyl glycosides : 2-hexyldecyl-p(la)-D -glucoside (2-HDG) and 2-hexyldecyl-p(la)-D -maltoside (2-HDM), whose structures are closely related to glycero-glycolipids. Both 2-HDG and 2-HDM have an identical hydrophobic chain (C 16), but the former consists a monosaccharide glucose head group, in contrast to the latter which has a disaccharide maltose unit. Consequently, their hydrophilic-lipophilic balance (HLB) is different. The results obtained have shown that these branched-ehain alkyl glycosides affect differently the stability of the nano-emu lsions. Compared to the model nanoemulsion, the presence of 2-HDG reduces the oil droplet size, whereas 2-HDM modify the properties of the model nano-emulsion system in terms of its droplet size and storage time stability at high temperature. These nano-emulsions have been proven capable of encapsulating ketoprofen, showing a fast release of almost 100% in 24 hours . Thus, both branched-chain alkyl glycosides are suitable as nano-cmulsion stabilizing agents and as drug delivery systems in the future

Topics: QD Chemistry
Year: 2014
OAI identifier: oai:eprints.um.edu.my:11093
Provided by: UM Digital Repository

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