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Detecting and Interpreting Heterogeneity and Publication Bias in Image-Based Meta-Analyses

By Thomas Maullin-Sapey, Camille Maumet and Thomas E. Nichols

Abstract

International audienceWith the increase of data sharing, meta-analyses are becoming increasingly important in the neuroimaging community. They provide a quantitative summary of published results and heightened confidence due to higher statistical power. The gold standard approach to combine results from neuroimaging studies is an Image-Based Meta-Analysis (IBMA) [1] in which group-level maps from different studies are combined.Recently, we have introduced the IBMA toolbox, an extension for SPM that provides methods for combining image maps from multiple studies [2]. However, the current toolbox lacks diagnostic tools used to assess critical assumptions of meta-analysis, in particular whether there is inter-study variation requiring random-effects IBMA, and whether publication bias is present. Here, we present two new tools added to the IBMA toolbox to detect heterogeneity and to assess evidence of publication bias

Topics: [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Publisher: HAL CCSD
Year: 2018
OAI identifier: oai:HAL:inserm-01933023v1
Provided by: HAL-Inserm
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