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CKD-EPI equation: A suitable Glomerular Filtration Rate estimate for drug dosing in HIV-infected patients

By A. Gagneux-Brunon, E. Botelho-Nevers, P. Delanaye, F. Lucht, A. Frésard, C. Cazorla, C. Guglielminotti, C. Fafin, C. Mariat and O. Moranne

Abstract

International audienceOBJECTIVES:To evaluate concordance between glomerular filtration rate (GFR) estimates (Cockcroft and Gault, modification of diet in renal diseases, chronic kidney disease epidemiology study group equations) for drug dosing in HIV-infected patients.PATIENTS AND METHODS:We performed a monocentric study. GFR was measured using the gold standard method (plasma clearance of iohexol) in 230 HIV-infected patients. Concordance rate was evaluated between measured GFR (mGFR) and estimated GFR (eGFR) for different GFR categories (GFR>90 mL/min, GFR70 mL/min, and GFR<70 mL/min). MDRD and CKD-EPI were used with and without indexation to body surface area (BSA).RESULTS:Mean age was 48±10 years, mean mGFR was 101±26 mL/min. Concordance between mGFR and eGFR estimated with CG, CKD-EPI (indexed and not indexed to BSA), or MDRD equations (not indexed to BSA) was similar (73%, 73%, 74%, and 73% respectively) for a breakpoint value of 90 mL/min for GFR. At this value, the concordance rate between mGFR and MDRD indexed to BSA was significantly lower (65%, P<0.05). Using 70 mL/min of GFR as the breakpoint value, all equations had similar concordance rates with mGFR (with or without indexation to BSA).CONCLUSION:CKD-EPI equation has the same concordance with GFR and with CG when used for drug dosing

Topics: CKD-EPI, Cockcroft and Gault, Cockcroft et Gault, Débit de filtration glomérulaire, Glomerular filtration rate, HIV infection, Infection par le VIH, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Publisher: 'Elsevier BV'
Year: 2017
DOI identifier: 10.1016/j.medmal.2017.04.001
OAI identifier: oai:HAL:hal-01895624v1
Provided by: HAL-UJM
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