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MiRNomics Reveals Breast Cancer Cells Cultured on 3D Scaffolds Better Mimic Tumors in Vivo than Conventional 2D Culture

By Gowri Manohari Balachander, Balaji Rajashekar, Prasad M Sarashetti, Annapoorni Rangarajan and Kaushik Chatterjee

Abstract

Tissue-engineering-based three-dimensional (3D) models offer several advantages over conventional two-dimensional (2D) cultures and can mimic tissues in vivo. Although studies have 3D scaffolds. The changes in the expression of several known microRNAs were similar to the changes reported in highly invasive cancers and their profiles highly correlated with 3D culture better mimics the tissue in vivo with novel insights into the roles of miRNAs in modulating metastatic progression

Topics: Molecular Reproduction, Development & Genetics
Publisher: 10.1021/acsbiomaterials.7b00694
Year: 2018
DOI identifier: 10.1021/acsbiomaterials.7b00694
OAI identifier: oai:eprints.iisc.ac.in:58885
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