EGb761, a Ginkgo Biloba Extract, Is Effective Against Atherosclerosis In Vitro, and in a Rat Model of Type 2 Diabetes

Lim Soo; Yoon Ji Won; Kang Seon Mee; Choi Sung Hee; Cho Bong Jun; Kim Min; Park Ho Seon; Cho Hyun Ju; Shin Hayley; Kim Young-Bum; Kim Hyo Soo; Jang Hak Chul; Park Kyong Soo

EGb761, a Ginkgo Biloba Extract, Is Effective Against Atherosclerosis In Vitro, and in a Rat Model of Type 2 Diabetes

Authors: Lim Soo
Yoon Ji Won
Kang Seon Mee
Choi Sung Hee
Cho Bong Jun
Kim Min
Park Ho Seon
Cho Hyun Ju
Shin Hayley
Kim Young-Bum
Kim Hyo Soo
Jang Hak Chul
Park Kyong Soo
Publication date: 2011
Publisher: Public Library of Science
Doi: DOI:10.1371/journal.pone.0020301

Abstract

and in a rat model of type 2 diabetes. were also decreased by the treatment of EGb761. Glucose homeostasis and circulating adiponectin levels were improved, and plasma hsCRP concentrations were decreased in the treatment groups. Caspase-3 activity and DNA fragmentation increased while monocyte adhesion and ICAM-1/VCAM-1 levels decreased significantly. Among subcomponents of EGb761, kaemferol and quercetin reduced VSMC migration and increased caspase activity.EGb761 has a protective role in the development of atherosclerosis and is a potential therapeutic agent for preventing atherosclerosis

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This paper was published in Public Library of Science (PLOS).

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