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Analysis of molecular changes during human melanocytic tumor progression.

By N.J. de Wit


Contains fulltext : 19619.pdf (publisher's version ) (Open Access)Melanoma is one of the most aggressive types of cancer, due to its potency to disseminate early in tumor progression. The incidence is still rising, even though the rate of change has leveled off in the last decade. As melanoma cells are relatively insensitive to classical systemic therapies, like chemotherapy and radiation therapy, the most effective treatment for melanoma patients is still surgical resection of the tumor before onset of the metastatic growth phase. Therefore, an accurate diagnosis of thin, biologically early melanoma lesions is very important. Despite the numerous melanoma markers that were previously identified, novel markers that could improve establishment of diagnosis and prognosis are still very welcome. Moreover, understanding of the processes involved in melanocytic tumorigenesis could be the basis for development of new diagnostic and prognostic tools and for the design of effective therapeutic protocols. To gain more insight in the molecular changes during melanoma progression, in this study, multiple array technologies were used to identify genes that show differential gene expression in different stages of melanocytic tumor progression. One differentially expressed gene, named MMA-1, was further characterized and its tissue-restricted expression showed that this gene belongs to the family of cancer/testis antigens. Various members of this family are already used in melanoma diagnostics and vaccination therapies for treatment of patients. Beside MMA-1, also other genes that showed differential expression in this study are candidate players in melanocytic tumor progression and are potent targets for diagnostic, prognostic and/or therapeutic interventionsRU Radboud Universiteit Nijmegen, 7 april 2005Promotor : Ruiter, D.J. Co-promotor : Muijen, G.N.P. van184 p

Topics: UMCN 1.2: Molecular diagnosis, prognosis and monitoring
Publisher: Nijmegen : Radboud University Nijmegen Medical Centre
Year: 2005
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Provided by: Radboud Repository

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