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Correlation between thermal and stability parameters of PC liposomes with trapped CF in DMSO/sucrose solutions with the band position of the OH stretching band (νOH) of the protective solutions.

By Bulat Sydykov (5484962), Harriëtte Oldenhof (5484965), Harald Sieme (651219) and Willem F. Wolkers (5484968)


<p>In panel A, the onset temperatures of melting for DMSO solutions without supplements (white circles), with 0.5 M sucrose (grey circles) and 1 M sucrose (black circles) are plotted against the positions of νOH. In panel B, leakage rates determined for liposomes frozen with the selected formulations of DMSO and sucrose; S1 (5% DMSO, 1 M sucrose), S2 (10% DMSO, 1 M sucrose), S3 (5% DMSO with 0.5 M sucrose), and S4 (10% DMSO with 0.5 M sucrose) during storage at −25°C are plotted against νOH. νOH was determined at room temperature.</p

Topics: Biophysics, Biotechnology, Ecology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, T g, mobility, sucrose, formulation, storage stability, DMSO solutions increases
Year: 2018
DOI identifier: 10.1371/journal.pone.0199867.g007
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Provided by: FigShare
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