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Video_7_Real-Time Monitoring of Cancer Cells in Live Mouse Bone Marrow.mov

By Sung Hwan Lee (1641649), Sang A Park (5581892), Yunyun Zou (2068453), Sang-Uk Seo (229293), Chang-Duk Jun (293883), Woo Jung Lee (286501), Young-Min Hyun (5581895) and Nam Hoon Cho (2047729)

Abstract

<p>Disseminated tumor cells in the bone marrow environment are the main cause of systemic metastasis after curative treatment for major solid tumors. However, the detailed biological processes of tumor biology in bone marrow have not been well defined in a real-time manner, because of a lack of a proper in vivo experimental model thereof. In this study, we established intravital imaging models of the bone marrow environment to enable real-time observation of cancer cells in the bone marrow. Using these novel imaging models of intact bone marrow and transplanted bone marrow of mice, respectively, via two-photon microscopy, we could first successfully track and analyze both the distribution and the phenotype of cancer cells in bone marrow of live mouse. Therefore, these novel in vivo imaging models for the bone marrow would provide a valuable tool to identify the biologic processes of cancer cells in a real-time manner in a live animal model.</p

Topics: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, two-photon microscopy, intravital imaging, bone marrow microenvironment, tumor cell dormancy, cancer cell
Year: 2018
DOI identifier: 10.3389/fimmu.2018.01681.s015
OAI identifier: oai:figshare.com:article/6891884
Provided by: FigShare
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