Model materials for validation of mathematical models describing intervertebral disc tissue behavior

Abstract

Model materials based on characteristic properties and behaviour of intervertebral disc tissue have been developed by means of an in-situ polymerization of hydrophilic copolymer gels in open cell microporous polyurethane (PUR)-foams. The random copolymer consists of sequences of acrylic acid and acrylamide groups. Confined swelling and compressions experiments have been performed on cylindrical model material specimens to study the model material behavior. The developed model materials are sensitive for changes in external ionic environment as expressed in a swelling of the material against 0.6 M and 0.2 M NaCl bathing solutions. Application of a mechanical load causes finite deformation. Similar material behavior is found for real intervertebral disc tissue. The influence of the initial acrylic-acid - acrylamide monomer ratio on model material behavior has been studied. Swelling rate and degree of swelling of the model materials can be controlled by adjustment of the amount of charged anionic (-C(O)O-) groups present in the copolymer ge

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This paper was published in NARCIS .

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