Acylated flavonol glycosides with anti-complement activity from Persicaria lapathifolia


During a search for biologically active compounds from traditional medicines, a crude extract of Persicaria lapathifolia was found to have anti- complement activity. Bioassay-guided chromatographic separation of the active constituents led to the isolation of a new acylated kaempferol glycoside (1) and three known acylated quercetin glycosides (2 - 4). The structures of compounds 1 - 4 were characterized as kaempferol 3-O-β-D-(6'-p- hydroxybenzoyl)-galactopyranoside, quercetin 3-O-β-D-(6'-feruloyl)- galactopyranoside, quercetin 3-O-β-D-(2'-galloyl)-rhamnopyranoside and quercetin 3-O-β-D-(2'-galloyl)-glucopyranoside, respectively. Compounds 1 - 4 showed strong anti-complement activity (IC50 values of 4.3, 9.7, 3.9 and 7.6 x 10-5 M, respectively) on the classical pathway of the complement. On the other hand, six isolated flavonol glycosides (510) did not show any activity on this system.ope

Similar works

Full text

oaioai:http://repository.kribb.re.kr:201005/4810Last time updated on 6/7/2018

This paper was published in KRIBB Repository.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.