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Efficacy of Methylprednisolone Pulse Followed by Oral Prednisone in Birdshot Chorioretinopathy

By M. Hafidi, O. Loria, Laurent Kodjikian, P. Denis, M.R. Ferrand, C. Broussolle and P. Seve

Abstract

International audiencePURPOSE: To report the outcomes of initial methylprednisolone pulse then oral prednisone in the treatment of birdshot chorioretinopathy (BSCR). METHODS: We retrospectively reviewed medical records of 21 BSCR patients, treated with initial methylprednisolone, prednisone, or immunosuppressive therapy. Main outcome measures were changes in visual acuity, intraocular inflammation, concomitant immunosuppressive drug or intravitreal steroid, and adverse events. RESULTS: In total, 14 patients were initially treated with methylprednisolone; four patients with prednisone; and three with immunosuppressive drug. Intraocular inflammation was controlled in 10 of 14 patients (71%) at 1 year, with a mean dose of 6.2 mg/day prednisone. Patients treated initially by methylprednisolone had improved visual acuity at 1 year, but it was not significantly different from patients treated initially by prednisone. CONCLUSIONS: Corticosteroid therapy, including initial methylprednisolone pulse then prednisone, was effective in stabilizing vision and decreasing inflammation in most patients with BSC

Topics: Medical Records, Prednisone, France, methods, Inflammation, Medicine, therapy, Patients, [SDV.CAN]Life Sciences [q-bio]/Cancer
Publisher: 'Informa UK Limited'
Year: 2016
DOI identifier: 10.1080/09273948.2016.1178778
OAI identifier: oai:HAL:hal-01797271v1
Provided by: HAL-HCL
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