Article thumbnail

Network Medicine for Alzheimer’s Disease and Traditional Chinese Medicine

By Juliet T. Jarrell, Li Gao, David S. Cohen and Xudong Huang

Abstract

Alzheimer’s Disease (AD) is a neurodegenerative condition that currently has no known cure. The principles of the expanding field of network medicine (NM) have recently been applied to AD research. The main principle of NM proposes that diseases are much more complicated than one mutation in one gene, and incorporate different genes, connections between genes, and pathways that may include multiple diseases to create full scale disease networks. AD research findings as a result of the application of NM principles have suggested that functional network connectivity, myelination, myeloid cells, and genes and pathways may play an integral role in AD progression, and may be integral to the search for a cure. Different aspects of the AD pathology could be potential targets for drug therapy to slow down or stop the disease from advancing, but more research is needed to reach definitive conclusions. Additionally, the holistic approaches of network pharmacology in traditional Chinese medicine (TCM) research may be viable options for the AD treatment, and may lead to an effective cure for AD in the future

Topics: Alzheimer’s disease, network medicine, inflammation, network and system pharmacology, traditional Chinese medicine, Organic chemistry, QD241-441
Publisher: MDPI AG
Year: 2018
DOI identifier: 10.3390/molecules23051143
OAI identifier: oai:doaj.org/article:76aa2f3dead24d61aca97b7bbadd8df4
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1420-3049 (external link)
  • http://www.mdpi.com/1420-3049/... (external link)
  • https://doaj.org/article/76aa2... (external link)

  • To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

    Suggested articles