Anti-inflammatory activity of Cissampelos sympodialis Eichl. (Menispermaceae) leaf extract

Abstract

La fracción acuosa del extracto etanólico obtenido de las hojas (AFL) de Cissampelos sympodialis ha sido evaluada con respecto a la actividad antiinflamatoria, ya que en medicina popular es usada para esta finalidad. En ratones el AFL (100mg/kg,ip) ha inhibido edema de la oreja por el 12-O-tetradecanoylphorbol 13-acetate y capsaicin en un 58% y 37%, respectivamente. La dosis eficaz de AFL para inhibir el edema de la pata de rata por carragenina fue 50 mgkg (el 24%). Los resultados preliminares de experimentos sobre la migración celular mostraron que AFL en dosis 100 y 200 mg/kg sc en ratas después de la administración de la carragenina inhibió la migración de neutrófilos en un 53% y 50%, respectivamente. Los resultados muestran que el AFL posee actividad antiinflamatoria.The aqueous fraction of the ethanolic extract obtained from the leaves (AFL) of Cissampelos sympodialis Eichl. (Menispermaceae) was evaluated for anti-inflammatory activity, as it is used in folk medicine for this purpose. In mice the AFL (100 mgkg, ip) inhibited both the 12-O-tetradecanoylphorbol 13- acetate and capsaicin- induced ear edema by 58% and 37%, respectively. The effective dose of AFL to inhibit the carrageenan-induced rat paw edema was 50 mgkg (24%). Preliminary results of experiments on cell migration showed that the administration (subcutaneous route) of AFL at 100 and 200 mgkg in rats inhibited the carrageenan-induced neutrophil migration measurement after the administration of the irritant by 53 and SO%, respectively. The results show that the AFL has anti-inflammatory activity.Colegio de Farmacéuticos de la Provincia de Buenos Aire

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