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An efficient and robust numerical algorithm for estimating parameters in turing systems

By M R Garvie, P. K. Maini and C Trenchea

Abstract

We present a new algorithm for estimating parameters in reaction–diffusion systems that display pattern formation via the mechanism of diffusion-driven instability. A Modified Discrete Optimal Control Algorithm (MDOCA) is illustrated with the Schnakenberg and Gierer–Meinhardt reaction–diffusion systems using PDE constrained optimization techniques. The MDOCA algorithm is a modification of a standard variable step gradient algorithm that yields a huge saving in computational cost. The results of numerical experiments demonstrate that the algorithm accurately estimated key parameters associated with stationary target functions generated from the models themselves. Furthermore, the robustness of the algorithm was verified by performing experiments with target functions perturbed with various levels of additive noise. The MDOCA algorithm could have important applications in the mathematical modeling of realistic Turing systems when experimental data are available

Topics: Biology and other natural sciences
Publisher: Elsevier
Year: 2010
DOI identifier: 10.1016/j.jcp.2010.05.040
OAI identifier: oai:generic.eprints.org:941/core69

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