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Spatiotemporal modelling of CheY complexes in escherichia coli chemotaxis

By M. J. Tindall, S. L. Porter, G H Wadhams, P. K. Maini and J. P. Armitage

Abstract

The chemotaxis pathway of Escherichia coli is one of the best studied and modelled biological signalling pathways. Here we extend existing modelling approaches by explicitly including a description of the formation and subcellular localization of intermediary complexes in the phosphotransfer pathway. The inclusion of these complexes shows that only about 60% of the total output response regulator (CheY) is uncomplexed at any moment and hence free to interact with its target, the flagellar motor. A clear strength of this model is its ability to predict the experimentally observable subcellular localization of CheY throughout a chemotactic response. We have found good agreement between the model output and experimentally determined CheY localization patterns

Topics: Biology and other natural sciences
Publisher: Elsevier
Year: 2009
DOI identifier: 10.1016/j.pbiomolbio.2009.06.005
OAI identifier: oai:generic.eprints.org:849/core69

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