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Biodistribution of process A and process B rhASA in rats.

By Teresa Wright (5122352), Aiqun Li (289891), Jason Lotterhand (334971), Anne-Renee Graham (5122349), Yan Huang (46805), Nancy Avila (5122355) and Jing Pan (95938)

Abstract

<p>Representative whole body autoradioluminograms showing tissue distribution of radioactivity 4 hours after a single intrathecal dose of (A) process A and (B) process B [<sup>125</sup>I]-rhASA 0.62 mg in male Sprague Dawley rats. rhASA, recombinant human arylsulfatase A.</p

Topics: Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Marine Biology, Cancer, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, nonclinical comparability program, process B rhASA, cynomolgus monkeys, B rhASA, immunotolerant MLD mice, lysosomal-associated membrane protein, manufacturing process changes, immunohistochemical staining, Nonclinical comparability studies, B rhASA-dosed mice, manufacturing process changes Recombinant, process B rhASA-related toxicity, Manufacturing process changes
Year: 2018
DOI identifier: 10.1371/journal.pone.0195186.g003
OAI identifier: oai:figshare.com:article/6161864
Provided by: FigShare
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