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Marine bacterial inhibitors from the sponge-derived fungus Aspergillus sp.

By Yaming Zhou, Abdessamad Debbab, Victor Wray, WenHan Lin, Barbara Schulz, Rozenn Trepos, Claire Pile, Claire Hellio, Peter Proksch and Amal H. Aly

Abstract

Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated from the Mediterranean sponge Tethya aurantium, yielded a new tryptophan derived alkaloid, 34(1-hydroxy-3-(2methylbut-3-en-2-y1)-2-oxoindolin-3-yl)methyl)-1-methyl-3,4-dihydrobenzo[e][1,41diazepine-2, 5-dione (1), and a new meroterpenoid, austalide R (2), together with three known compounds (3-5). The structures of the new compounds were unambiguously elucidated on the basis of extensive one and twodimensional NMR (1H, 13C, COSY, HMBC, and ROESY) and mass spectral analysis. Interestingly, the compounds exhibited antibacterial activity when tested against a panel of marine bacteria, with 1 selectively inhibiting Vibrio species and 2 showing a broad spectrum of activity. In contrast, no significant activity was observed against terrestrial bacterial strains and the murine cancer cell line L5178Y. (C) 2014 Elsevier Ltd. All rights reserved.Chemistry, OrganicSCI(E)2ARTICLEamal.hassan@uni-duesseldorf.de172789-27925

Topics: Aspergillus, Marine natural products, Sponge-derived fungi, Tethya aurantium, MAIZE BRAN, CYTOCHALASINS, METABOLITES, DERIVATIVES, AUSTALIDES, USTUS
Publisher: 四面体通讯
Year: 2014
DOI identifier: 10.1016/j.tetlet.2014.02.062
OAI identifier: oai:localhost:20.500.11897/213554
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