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NF-κB和STAT3对宫颈癌作用的研究进展

By 方禛浩, 谌錾, 李妍静 and 朱丽红

Abstract

宫颈癌是女性第二好发的恶性肿瘤,对于晚期患者,放疗联合化疗是主要的治疗方法.但放化疗诱导的炎症使肿瘤产生了治疗抵抗并引起正常组织的损伤.其中激活的转录因子核因子-κB (nuclear factor-κB,NF-κB)和信号转导及转录激活因子3 (signal transducer and activator of transduction 3,STAT3),是炎症反应的中心环节.两者通过激活调控肿瘤生长增殖、抗凋亡、血管发生及侵袭转移的基因,从而降低宫颈癌对放化疗的敏感性.因此寻找抑制这两个分子的药物对于晚期宫颈癌的治疗显得尤为重要.中国科技核心期刊(ISTIC)0181-831

Publisher: 中国妇产科临床杂志
Year: 2013
DOI identifier: 10.3969/j.issn.1672-1861.2013.01.033
OAI identifier: oai:localhost:20.500.11897/113624
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