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Interim results of an ecological experiment — Conjugate vaccination against the pneumococcus and serotype replacement

By William P Hausdorff and William P Hanage

Abstract

Streptococcus pneumoniae has more than 95 serotypes, each of which presumably can cause sepsis, meningitis, pneumonia, and acute otitis media. Pneumococcal conjugate vaccines (PCV) targeted against a limited number of serotypes have nonetheless revealed an impressive impact on each manifestation of pneumococcal disease. At the same time, growing evidence of significant non-vaccine type (NVT) replacement disease following implementation of infant PCV programs has raised questions about the long-term viability of PCV immunization strategies and how to optimize PCV formulations. We discuss here theoretical and practical considerations regarding serotype replacement, and provide a snapshot of the most important NVT types seen to date after implementation of the 2 higher-valent PCVs

Topics: Streptococcus pneumoniae, Pneumococcal conjugate vaccines, Invasive Pneumococcal Disease, Serotype replacement, Meningitis, Acute Otitis Media
Publisher: 'Informa UK Limited'
Year: 2016
DOI identifier: 10.1080/21645515.2015.1118593.
OAI identifier: oai:dash.harvard.edu:1/29408351
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