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Early outcomes after transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma: One centre's experience

By Leong S.C., Kathan C. and Mortimore S.


Objectives: To review early oncological outcomes following transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma. Design: Retrospective review of hospital electronic database. Setting: Large district general hospital in England, UK.Main outcome measures: Patients' three-year disease-specific survival and disease-free survival were evaluated, including post-operative complications, voice quality and swallowing status. Results: Seventy-seven patients (16 women and 61 men) were identified. Transoral laser excision of squamous cell carcinoma of the larynx was undergone by 65 patients, and the same procedure in the hypopharynx by 12. Patients with laryngeal cancer had statistically better disease-specific survival than those with hypopharyngeal cancer (p=0.021), although the cumulative disease-free survival probability was 0.71 for both larynx and hypopharynx groups. Patients who underwent laryngectomy following failed laser treatment or as a salvage procedure had poorer outcomes.Conclusions: The overall results of this study were comparable with those of other, larger studies. At three-year follow up, cumulative disease-specific survival probabilities were 0.92 and 0.71 for laryngeal and hypopharyngeal squamous cell carcinoma, respectively. Copyright © JLO (1984) Limited 2009

Topics: Larynx neoplasms, Laser therapy, Pharynx neoplasms, adult, carbon dioxide laser, controlled study, disease free survival, female, follow up, human, hypopharynx carcinoma, laryngectomy, larynx carcinoma, major clinical study, male, outcome assessment, overall survival, postoperative complication, retrospective study, review, salvage therapy, squamous cell carcinoma, survival rate, swallowing, treatment outcome, United Kingdom, voice, Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Disease-Free Survival, England, Female, Hospitals, General, Humans, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Laser Therapy, Lasers, Gas, Male, Middle Aged, Neoplasm Recurrence, Local, Outcome Assessment (Health Care), Retrospective Studies, Survival Analysis
Publisher: 'Cambridge University Press (CUP)'
Year: 2010
DOI identifier: 10.1017/S0022215109991514
OAI identifier:
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