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Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis

By H.M.A. Hofstee, A. Vonk noordegraaf, A.E. Voskuijl, B.A.C. Dijkmans, P.E. Postmus, Y.M. Smulders and E.H. Serne


0.001). Capillary density in healthy controls (9.87/mm) was significantly higher when compared with SSc-nonPAH (6.56/mm), SSc-PAH (4.33/mm) and with IPAH (7.86/mm). No differences in capillary dimensions were present between healthy controls and IPAH. Capillary density correlated with mean pulmonary arterial pressure (PAP) at rest in SSc-PAH at rest (r = -0.58, p = 0.039) and IPAH (r = -0.67, p = 0.001). CONCLUSIONS: Reduction of nailfold capillary density, but not capillary loop dimensions is associated with PAH, and correlates with the severity of PAH in both SSc and IPAH. This suggests that either systemic microvascular changes play a part in the development of PAH, or that PAH itself contributes to systemic microvascular change

Year: 2009
DOI identifier: 10.1136/ard.2007.087353
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Provided by: DSpace at VU

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