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Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria.

By E Belnoue, FT Costa, AM Vigario, T Voza, F Gonnet, I Landau, N. van Rooijen, M Mack, WA Kuziel and L Renia


Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8(+) T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8(+) T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8(+) T-cell migration to the brain was not abolished

Year: 2003
DOI identifier: 10.1128/IAI.71.6.3648-3651.2003
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Provided by: DSpace at VU

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