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Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography

By C.E. van den Brom, M.C. Huisman, R. Vlasblom, N. Boontje, S. Duijst, J.M. Lubberink, C.F.M. Molthoff, A.A. Lammertsma, J. van der Velden, C. Boer, D.M. Ouwens and M. Diamant

Abstract

0.05). CONCLUSION: Using PET and echocardiography, we found increases in myocardial FA oxidation with a concomitant decrease of insulin-mediated myocardial glucose utilisation in early DCM. In addition, the latter was associated with impaired myocardial function. These in vivo data expand previous in vitro findings showing that early alterations in myocardial substrate metabolism contribute to myocardial dysfunctio

Year: 2009
DOI identifier: 10.1186/1475-2840-8-39
OAI identifier: oai:dare.ubvu.vu.nl:1871/20324
Provided by: DSpace at VU
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