Background Littleisknown aboutthe cost-effectiveness of preventingmental disorders. Aims To study the cost-effectiveness of care asusualplusminimal contact psychotherapyrelative to usual care alone inpreventingdepressive disorder. Method An economic evaluationwas conducted alongside a randomised clinical trial.Primarycare patientswith subthreshold depressionwere assignedto minimal contactpsychotherapyplususual care (n¼107) or to usual care alone (n¼109). Results Primarycarepatientswithsubthreshold depression benefited from minimal contactpsychotherapy asit reducedthe riskofdevelopinga full-blown depressive disorder from18% to12%.In addition, this interventionhad a 70% probabilityof beingmore cost-effective thanusual care alone.Asensitivityanalysis indicatedthe robustness of these results. Conclusions Over1year adjunctive minimal contactpsychotherapyimproved outcomes and generatedlower costs.This interventionis therefore superior to usual care aloneinterms of cost-effectiveness
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