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Effect of cessation of GH treatment on cognition during transition phase in Prader-Willi syndrome: Results of a 2-year crossover GH trial

By R.J. (Renske) Kuppens, E.F. Mahabier, N.E. (Nienke) Bakker, E.P.C. (Elbrich) Siemensma, S.H. (Stephanie) Donze and A.C.S. (Anita) Hokken-Koelega


Background: Patients with Prader-Willi syndrome (PWS) have a cognitive impairment. Growth hormone (GH) treatment during childhood improves cognitive functioning, while cognition deteriorates in GH-untreated children with PWS. Cessation of GH treatment at attainment of adult height (AH) might deteriorate their GH-induced improved cognition, while continuation might benefit them. We, therefore, investigated the effects of placebo versus GH administration on cognition in young adults with PWS who were GH-treated for many years during childhood and had attained AH

Topics: Cognition, Growth hormone treatment, Prader-Willi syndrome, Young adults
Publisher: 'Springer Science and Business Media LLC'
Year: 2016
DOI identifier: 10.1186/s13023-016-0535-7
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