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Role of D2-like Heteroreceptor Complexes in the Effects of Cocaine,Morphine, and Hallucinogens

By O Borroto-Escuela D., K Wydra, L Ferraro, A Rivera, M Filip and K Fuxe


We describe the potential functional role of heteromers in disease progression, specifically with respect to the etiology of cocaine addiction. We obtained indications for a role of adenosine A2AR and dopamine D2R (A2AR–D2R) heteroreceptor complexes in cocaine addiction (Filip et al., 2012; Fuxe, Borroto-Escuela, et al., 2014). Our working hypothesis is that A2AR–D2R heteroreceptor complexes are critically involved in cocaine addiction and more specifically that the activation of the A2AR protomer of the heteromer inhibits the development of addictive behavior through inhibition of the D2R protomer recognition and signaling

Publisher: Elsevier
Year: 2016
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