Increasing elastin fibre production in a tissue engineered mesh for pelvic floor surgery

Abstract

yesPolypropylene mesh for pelvic floor surgery is associated with serious complications ( e.g. erosion). A biodegradable tissue engineered mesh composed of a polylactic acid (PLA) scaffold seeded with autologous cells is a promising alternative. However, thus far elastin content (important for elastic recoil) in this tissue has been low. We aimed to increase elastin expression and test the resultant tensile properties