Asymmetric distribution of centromeric components in midgut stem cells and their role in cell types with varying differentiating potential

Abstract

CENP-A is a histone variant critical for centromere function during mitosis. We have analyzed CENP-A in stem cells of the fly intestine and found an symmetric inheritance of pre-existing and newly synthesized CENP-A. CENP-A and its loading factor CAL1 are essential in differentiated cells, suggesting non-mitotic role

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