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The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme cholesterol side chain cleavage

By Sabbir Ahmed

Abstract

The previously reported substrate-heme complex approach is used to study the binding of type II inhibitors of the enzyme cholesterol side chain cleavage (CSCC), a cytochrome P-450 dependent enzyme involved in the oxidative cleaveage of the C(20)-C(22) bond of cholesterol. Using the derived model, we have rationalised the inhibitory activity of a number of compounds including aminoglutethimide and pyridoglutethimide and the enantiomers of ketoconazole

Topics: chemistry
Publisher: Elsevier
Year: 2000
DOI identifier: 10.1006/bbrc.2000.3209
OAI identifier: oai:eprints.kingston.ac.uk:7242
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