The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators

Abstract

A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity

Similar works

Full text

thumbnail-image

Kingston University Research Repository

redirect
Last time updated on 11/04/2012

This paper was published in Kingston University Research Repository.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.