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The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators

By Elizabeth Tyrrell, Kibur Hunie Tesfa, Iain Greenwood and Alistair Mann


A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity

Topics: chemistry
Publisher: Elsevier
Year: 2008
DOI identifier: 10.1016/j.bmcl.2007.11.135
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