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Lack of FGF20 results in undifferentiated lateral compartment cells.

By Sung-Ho Huh (191072), Jennifer Jones (92320), Mark E. Warchol (75297) and David M. Ornitz (191076)

Abstract

<p>(A) Co-immunostaining of E-Cadherin and Myo6 showing that E-Cadherin stains lateral compartment cells in <i>Fgf20<sup>βGal/+</sup></i> cochlea (A, upper). In <i>Fgf20<sup>βGal/βGal</sup></i> cochlea, E-Cadherin stains all lateral compartment cells including cells localized in the region between sensory patches (A, lower, arrow). (B) Co-immunostaining of Sox2 and phalloidin showing that Sox2 labels supporting cells in <i>Fgf20<sup>βGal/+</sup></i> cochlea (B, upper). In <i>Fgf20<sup>βGal/βGal</sup></i> cochlea, the region between patches was marked by strong Sox2 staining (B, lower, arrows). (C) Co-immunostaining of p27 and phalloidin showing that p27 stains supporting cells in <i>Fgf20<sup>βGal/+</sup></i>cochlea (C, upper). In <i>Fgf20<sup>βGal/βGal</sup></i> cochlea, the region between patches was marked by strong p27 staining (C, lower, arrows). (D) Co-immunostaining of Sox2 and Prox1 of <i>Fgf20<sup>βGal/βGal</sup></i> explants treated with or without FGF9. Without FGF9 treatment (left), Sox2+/Prox1− cells were localized in the region between sensory patches (arrows). Treatment of <i>Fgf20<sup>βGal/βGal</sup></i> explants with FGF9 induced Sox2+/Prox1− cells to express Prox1 (right).</p

Topics: Medicine, Genetics, Neuroscience, Physiology, Developmental Biology, fgf20, undifferentiated, lateral, compartment
Year: 2012
DOI identifier: 10.1371/journal.pbio.1001231.g005
OAI identifier: oai:figshare.com:article/367197
Provided by: FigShare
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