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Constant Flow-Driven Microfluidic Oscillator for Different Duty Cycles

By Sung-Jin Kim (583410), Ryuji Yokokawa (2000455), Sasha Cai Lesher-Perez (2123473) and Shuichi Takayama (234332)


This paper presents microfluidic devices that autonomously convert two constant flow inputs into an alternating oscillatory flow output. We accomplish this hardware embedded self-control programming using normally closed membrane valves that have an inlet, an outlet, and a membrane-pressurization chamber connected to a third terminal. Adjustment of threshold opening pressures in these 3-terminal flow switching valves enabled adjustment of oscillation periods to between 57 and 360 s with duty cycles of 0.2–0.5. These values are in relatively good agreement with theoretical values, providing the way for rational design of an even wider range of different waveform oscillations. We also demonstrate the ability to use these oscillators to perform temporally patterned delivery of chemicals to living cells. The device only needs a syringe pump, thus removing the use of complex, expensive external actuators. These tunable waveform microfluidic oscillators are envisioned to facilitate cell-based studies that require temporal stimulation

Topics: Biophysics, Medicine, Neuroscience, Physiology, Biotechnology, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, duty cycles, waveform oscillations, terminal, tunable waveform microfluidic oscillators, oscillatory flow output, oscillation periods, membrane valves, Different Duty CyclesThis paper, flow inputs, microfluidic devices, threshold opening pressures
Year: 2012
DOI identifier: 10.1021/ac202866b.s001
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Provided by: FigShare
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